Sodium lauryl sulfate

(Dodecyl alcohol, hydrogen sulfate, sodium salt, Dodecyl sodium sulfate, Dodecyl sulfate sodium, Dodecyl sulfate sodium salt, Dodecyl sulfate, sodium salt, Lauryl sodium sulfate, Lauryl sulfate sodium, Lauryl sulfate sodium salt, Lauryl sulfate, sodium salt, Laurylsiran sodny [czech], Lauyl sodium sulfate, Monododecyl sodium sulfate, N-dodecyl sulfate sodium, NADDS, NALS, Natrium laurylsulfuricum, Natriumlaurylsulfat, SDS, Sodium dodecyl sulfate, Sodium lauryl sulphate, Sodium monododecyl sulfate, Sodium monolauryl sulfate, Sodium n-dodecyl sulfate, Sodiumlauryl ether sulfate, Sulfuric acid dodecyl ester sodium salt, Sulfuric acid monododecyl ester sodium salt, Sulfuric acid, monododecyl ester, sodium salt)

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Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Indication: 
SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.
Categories: 
Mechanism of Action: 
Like other surfactants, SLS is amphiphilic. It thus migrates to the surface of liquids, where its alignment and aggregation with other SLS molecules lowers the surface tension. This allows for easier spreading and mixing of the liquid. SLS has potent protein denaturing activity and inhibits the infectivity of viruses by by solubilizing the viral envelope and/or by denaturing envelope and/or capsid proteins.
Pharmacology: 
SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.
Toxicity: 
Oral (LD50): Acute: 1288 mg/kg [Rat]
Affected organisms: 
Type: 
Group: 
Experimental properties: 
Water Solubility:
1E+005 mg/L
Melting Point:
205.5 °C
logP:
1.60
Brands: 
WAQE,
General References: 
# Agner T: Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol. 1991;71(4):296-300. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1681644 # Marrakchi S, Maibach HI: Sodium lauryl sulfate-induced irritation in the human face: regional and age-related differences. Skin Pharmacol Physiol. 2006;19(3):177-80. Epub 2006 May 4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16679819 # Loffler H, Effendy I: Skin susceptibility of atopic individuals. Contact Dermatitis. 1999 May;40(5):239-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10344477 # Chahine L, Sempson N, Wagoner C: The effect of sodium lauryl sulfate on recurrent aphthous ulcers: a clinical study. Compend Contin Educ Dent. 1997 Dec;18(12):1238-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9656847 # Herlofson BB, Barkvoll P: The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers. Acta Odontol Scand. 1996 Jun;54(3):150-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8811135 # Piret J, Desormeaux A, Bergeron MG: Sodium lauryl sulfate, a microbicide effective against enveloped and nonenveloped viruses. Curr Drug Targets. 2002 Feb;3(1):17-30. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11899262
Prices: 
Carrington whirlpool solution
ml
$0.01
Sodium lauryl sulfate cryst
g
$0.03
Monogen powder
g
$0.09
Mixtures: 
For sope
sodium lauryl sulfate + stearic acid
Plax anti-plaque den rinse peppermint liq
sodium benzoate + sodium lauryl sulfate + sodium salicylate
Plax anti-plaque dent rinse soft mint liq
sodium benzoate + sodium lauryl sulfate + sodium salicylate
Plax anti-plaque dental rinse
sodium benzoate + sodium lauryl sulfate + sodium salicylate
Cas Number: 
151-21-3
External identifiers: 
ChEBI:
8984
KEGG Compound:
C11166
KEGG Drug:
D01045
PharmGKB:
PA451398