Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.) Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care.
For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
Mechanism of Action:
Hyoscyamine competes favorably with acetylcholine for binding at muscarinic receptors in the salivary, bronchial, and sweat glands as well as in the eye, heart, and gastrointestinal tract. The actions of hyoscyamine result in a reduction in salivary, bronchial, gastric and sweat gland secretions, mydriasis, cycloplegia, change in heart rate, contraction of the bladder detrusor muscle and of the gastrointestinal smooth muscle, and decreased gastrointestinal motility.
L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent.
Absorbed totally and completely by sublingual administration as well as oral administration.
The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Hyoscyamine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide and Hyoscyamine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
- Take 30 minutes before meals, and at bedtime.
Symptoms of overdose include headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. LD50=mg/kg(orally in rat)
3560 mg/L (at 20 °C)
Levsin 0.125 mg tablet
Symax-sl 0.125 mg tablet sl
Symax fastabs 0.125 mg tablet
Levsin/SL 0.125 mg Sublingual Tabs
Symax-sr 0.375 mg tablet
Levbid 0.375 mg tablet sa
Hyoscyamine Sulfate CR 0.375 mg 12 Hour tablet
Levbid er 0.375 mg tablet
Levbid 0.375 mg 12 Hour tablet
Symax-SL 0.125 mg Sublingual Tabs
Symax Duotab 0.375 mg Controlled Release Tabs
Hyoscyamine sulfate powder
Levsin 0.5 mg/ml ampul
Levsin 0.125 mg/ml Solution 15ml Bottle
Anaspaz 0.125 mg tablet sl
Levsin 0.125 mg/5ml Elixir
Anaspaz 0.125 mg Dispersible Tablet
Hyoscyamine sul 0.15 mg tablet sl
Hyoscyamine 0.125 mg tablet sl
Hyoscyamine su 0.125 mg tablet
Hyoscyamine sulf 0.125 mg tablet
Hyoscyamine Sulfate 0.125 mg Dispersible Tablet
Hyomax-sl 0.125 mg tablet sl
Hyoscyamine Sulfate 0.125 mg Sublingual Tabs
Nulev 0.125 mg tablet
Hyoscyamine Sulfate 0.125 mg tablet
Levsin-sl 0.125 mg tablet sl
Drugs Product Database (DPD):